Our group has an important transversal component, and  research linesfocused in the development of test for new drugs, biomarkers, or molecules ofinterest for the research.
Our main areas of interest are:
1) Massive data analysis.  We are investigating how use the millions of biological results generated in our clinical laboratories to extract new information and improve the diagnosis ofdiseases, defining reference intervals tailored toeach individual, and aiming towards a personalized medicine.
2) Development of analytical methods for new drugs and biomarkers. We use targeted mass spectrometry to detect and measure proteinsand molecules of interest, and genetic tools for DNA and RNA markers. We workin close collaboration with pathophysiology oriented research groups (rarediseases, oncology, infectious diseases, neurology, and nephrology) to developthe measure of clinically useful biomarkers and drugs or tounderstand the etiology of diseases of unknown cause.

Group Leader
Francisco Rodríguez Frias

Principal Investigator (PI)
Rosanna Paciucci

Researchers
Juan López Hellin, Clara Carnicer Cáceres, Maria Francesca Cortese, Roser Ferrer Costa, Jose Antonio Arranz Amo

PhD Students
Albert Blanco Grau, Luz Maria Cruz Carlos, Pablo Gabriel Medina, Yolanda Villena Ortiz, Noelia Diaz Troyano, Luisa Martínez Sánchez, Raquel Barquin del Pino, Laura Castillo Ribelles, Selene Garcia Garcia, Beatriz Pacin Ruiz, Marta Vila Salvador, Emily Toscano Guerra, Alba Estela Garcia

Lab Technicians
Pilar Bonet Palomares, Angeles Esteban Pepió, Francisco Torralba

37

PUBLICATIONS

254

IMPACT FACTOR

6.87

AVERAGE IMPACT FACTOR

SELECTED ARTICLES

Jacobs-Cachá C, Puig-Gay N, Vergara A, Gabaldon MA, Sellarés J, Villena-Ortiz Y, Agraz I, Moreso F, Soler MJ, Serón D, López-Hellín J
Specific Tubular ApoA-I Distribution Is Associated to FSGS Recurrence after Kidney Transplantation
J Clin Med. 2021 May 18;10(10):2174
DOI: doi: 10.3390/jcm10102174.
IF: 5.58

Carnicer-Cáceres C, Arranz-Amo JA, Cea-Arestin C, Camprodon-Gomez M, Moreno-Martinez D, Lucas-Del-Pozo S, Moltó-Abad M, Tigri-Santiña A, Agraz-Pamplona I, Rodriguez-Palomares JF, Hernández-Vara J, Armengol-Bellapart M, Del-Toro-Riera M, Pintos-Morell G
Biomarkers in Fabry Disease. Implications for Clinical Diagnosis and Follow-up.
J Clin Med. 2021 Apr 13;10(8):1664.
DOI: doi: 10.3390/jcm10081664.
IF: 5.58

García-López M, Lens S, Pallett LJ, Testoni B, Rodríguez-Tajes S, Mariño Z, Bartres C, García-Pras E, Leonel T, Perpiñán E, Lozano JJ, Rodríguez-Frías F, Koutsoudakis G, Zoulim F, Maini MK, Forns X, Pérez-Del-Pulgar S.
Viral and immune factors associated with successful treatment withdrawal in HBeAg-negative chronic hepatitis B patients
J Hepatol. 2021 May;74(5):1064-1074.
DOI: doi: 10.1016/j.jhep.2020.11.043.
IF: 25.08

Nakanishi T, Pigazzini S, Degenhardt F, Cordioli M, Butler-Laporte G, Maya- Miles D, Bujanda L, Bouysran Y, Niemi ME, Palom A, Ellinghaus D, Khan A, Martínez-Bueno M, Rolker S, Amitrano S, Roade Tato L, Fava F; FinnGen; COVID-19 Host Genetics Initiative (HGI), Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernández-Cadenas I, Holter JC, Banales JM, Frithiof R, Kiryluk K, Duga S, Asselta R, Pereira AC, Romero-Gómez M, Nafría-Jiménez B, Hov JR, Migeotte I, Renieri A, Planas AM, Ludwig KU, Buti M, Rahmouni S, Alarcón-Riquelme ME, Schulte EC, Franke A, Karlsen TH, Valenti L, Zeberg H, Richards JB, Ganna A.
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.
J Clin Invest. 2021 Dec 1;131(23):e152386.
DOI: doi: 10.1172/JCI152386.
IF: 14.81

Garcia-Garcia S, Cortese MF, Tabernero D, Gregori J, Vila M, Pacín B, Quer J, Casillas R, Castillo-Ribelles L, Ferrer-Costa R, Rando-Segura A, Trejo-Zahínos J, Pumarola T, Casis E, Esteban R, Riveiro-Barciela M, Buti M, Rodríguez-Frías F
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA: Different quasispecies?
World J Gastroenterol. 2021 Nov 7;27(41):7144-7158.
DOI: doi: 10.3748/wjg.v27.i41.7144
IF: 5.74

Role of Apolipoprotein A-Ib in the idiopathic nephrotic syndrome
Principal Investigator: Conxita Jacobs
Agency: Fundació la Marató de TV3
Funding: 199,966€
Period: 2021-2023

Immune profiling to guide host-directed interventions to cure HBV infections (IP-cure-B)
Principal Investigator: Fabien Zoulim, Francisco Rodriguez Frias
Agency: European comisión (H2020-EU.3.1.3.)
Funding: 250,000€
Period: 2020-2022

Estudio de la quasiespecies del gen X en ARN circulante del virus de la hepatitis B (ARN-VHB): en búsqueda de nuevos factores pronósticos y dianas para terapia génica
Principal Investigator: Francisco Rodríguez Frías
Agency: Instituto de Salud Carlos III (PI18/01436)
Funding: 159,720€
Period: 2019-2021

Early detection of recurrence for a personalized therapy of hormone-naïve prostate cancer patients with metastatic disease
Principal Investigator: Rosanna Paciucci
Agency: Ministerio de Ciencia, Innovación y Universidades. RTI 2018-096055-B-100.
Funding: 108,900€
Period: 2019-2021