Diagnostic Nanotools develops new diagnostic tools. In 2021, we worked in the context of projects 2019PROD00086 and DTS20/00093, funded by AGAUR and ISCIII, to develop a synthetic reagent to replace erythrocytes in classica haemagglutination assays used worldwide to track the annual flu epidemics. This product detects several influenza virus types and could be mass produced for global distribution. Over 2022, with the support of a Consolidate project granted by La Caixa Foundation, we envision technology transfer to a company. Besides, we produced point-of-care diagnostic devices for the fast, simple and quantitative detection of malaria. Among others, we showed that assay automation using paper devices provides efficient biomarker detection with little user intervention. Two projects just granted (AC21_2/00021 EuroNanoMedand PID2020-118904RB-C22 RETOS) will allow us to improve the system and apply it also to respiratory infections.

Group Leader
Eva Baldrich Rubio

PhD Students
Ana Sánchez Cano, Kevin Ricardo Arias Alpizar

Lab Technicians
Erica de la Serna Botello, Judit Prat Trunas








A Sanchez-Cano, G Ruiz-Vega, S Vicente-Gómez, E de la Serna, E Sulleiro, I Molina, A Sánchez-Montalvá, E Baldrich
Development of a fast chemiluminescent magneto-immunoassay for sensitive Plasmodium falciparum detection in whole blood
Anal Chem. 2021 93: 12793–12800
DOI: DOI: 10.1021/acs.analchem.1c03242
IF: 6.986

IC Samper, A Sánchez-Cano, W Khamcharoen, I Jang, W Siangproh, E Baldrich, BJ Geiss, DS Dandy, CS Henry
Electrochemical capillary-flow immunoassay for detecting anti-SARS-CoV-2 nucleocapsid protein antibodies at the point of care
ACS Sensors. 2021 6: 4067–4075
DOI: DOI: 10.1021/acs.analchem.1c03242
IF: 7.711

A Sánchez-Cano, C Andrés, JR Herance, T Pumarola, A Antón, E Baldrich
Detection of viruses and virus-neutralizing antibodies using synthetic erythrocytes: toward a tuneable tool for virus surveillance
ACS Sensors. 2021 6: 83−90
DOI: DOI: 10.1021/acssensors.0c01830
IF: 7.711

E de la Serna, K Arias-Alpízar, LN Borgheti-Cardoso, A Sanchez-Cano, E Sulleiro, F Zarzuela, P Bosch-Nicolau, F Salvador, I Molina, M Ramírez, X Fernàndez-Busquets, A Sánchez-Montalvá, E Baldrich
Detection of Plasmodium falciparum malaria in one hour using a simplified enzyme-linked immunosorbent assay
Anal Chim Acta. 2021 1152: 338254
DOI: DOI: 10.1016/j.aca.2021.338254
IF: 6.558

K Jaimes Merazzo, J Totoricaguena-Gorriño, E Fernández-Martín, F.J del Campo, E Baldrich
Smartphone-Enabled Personalized Diagnostics: Current Status and Future Prospects
Diagnostics. 2021, 11: 1067
DOI: DOI: 10.3390/diagnostics11061067
IF: 3.706

Desarrollo de tests rápidos y ultrasensibles para infecciones respiratorias (PID2020-118904RB-C22)
Principal Investigator: Eva Baldrich
Agency: Ministerio de Ciencia e Innovación – Convocatoria Proyectos de I+D+i Orientada a los Retos de la Sociedad
Funding: 73,810 €
Period: 2021-2024

Dispositivo diagnóstico sintético como sustituto de los eritrocitos animales en los ensayos de hemaglutinación clásicos: aplicación a la vigilancia de los virus de la gripe (DTS20/00093)
Principal Investigator: Eva Baldrich
Agency: Instituto de Salud Carlos III – Convocatoria de Proyectos de Desarrollo Tecnológico en Salud
Funding: 104,500 €
Period: 2021-2022

Eritrocits sintètics per a la vigilància del virus de la grip (SIFECAT: IU68-017255 / número expedient: 2019PROD00086)
Principal Investigator: Eva Baldrich
Agency: Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR), Departament d'Empresa i Coneixement, Generalitat de Catalunya. Projectes Producte
Funding: 100,000 €
Period: 2020-2022

Grups de Recerca Consolidats. Ajuts de potenciació al Grup de Nanoeines Diagnòstiques – Diagnostic nanotools (2017 SGR 240)
Principal Investigator: Eva Baldrich
Agency: Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR). Departament d’Empresa i Coneixement. Generalitat de Catalunya
Funding: --
Period: 2018-2021

Reagents and fast methods for pathogen characterization and serology testing
Priority Number: PCT/EP2020/066292
Priority Date: 12/06/2020
Applicants: 100% VHIR