Our work is focused in the characterization of the physiological roles of the death receptor antagonist, FAIM-L. We have evidenced its interaction in neurons with XIAP and Siva-1, confirming that FAIM-L is involved in neuronal plasticity processes through stabilization of XIAP and modulating caspases activity. We have recently characterized an interaction of FAIM-L with tau, a key protein in Alzheimer’s disease, thus showing the relevance of FAIM-L in neurodegenerative processes. In addition, results in mice models show a key role for FAIM-L in retinal homeostasis, by controlling glial response, ubiquitinated protein aggregation, and vascular leakage.
We are now developing new tools to characterize FAIM-L expression and to modulate its levels in different animal models of AD, with the aim to better knowing its role in neuron physiology and pathologies related with neurodegeneration.

Group Leader
Joan Xavier Comella Carnicé

Montserrat Solé Piñol

PhD Students
Raquel Badillos Rodríguez, Anna Martínez Sirés, Mireia Turch Anguera

Nursing and Technical Staff
Joaquín López Soriano








Sirés A, Turch-Anguera M, Bogdanov P, Sampedro J, Ramos H, Ruíz Lasa A, Huo J, Xu S, Lam KP, López-Soriano J, Pérez-García MJ, Hernández C, Simó R, Solé M, Comella JX.
Faim knockout leads to gliosis and late-onset degeneration of photoreceptors in mice retines
J. Neurosci Res. 2021; 99(12):3103-3120
DOI: DOI:10.1002/jnr.24978
IF: 4.164

Sansa A, de la Fuente S, Comella JX, Garcera A & Soler RM.
Intracellular pathways involved in cell survival are deregulated in mouse and human Spinal Muscular Atrophy motoneurons
Neurobiol. Dis. 2021, Apr 13;155:105366
DOI: doi: 10.1016/j.nbd.2021.105366
IF: 5.996

Apoptosi i Neurodegeneració
Principal Investigator: Joan X. Comella
Agency: Generalitat de Catalunya – AGAUR
Funding: 20,000€
Period: 2018-2021

Papel del antagonista de receptores de muerte, FAIM-L, en la progresión de la enfermedad de Alzheimer
Principal Investigator: Joan X. Comella
Agency: Ministerio de Ciencia e Innovación
Funding: 180,000 €
Period: 2020-2022

Retinal and cognitive dysfunction in type 2 diabetes: unravelling the common pathways and identification of patients at risk of dementia (RECOGNISED)
Principal Investigator: Rafael Simó
Agency: European Union
Funding: 5,998,272 €
Period: 2020-2023