Drug resistance is the principal limiting factor to achieving good survival rates in patients with cancer. The identification of potential biomarkers for diagnosis and prognostic prediction, as well as the design of new molecular-targeted treatments, will be essential to improving head and neck squamous cell carcinoma (HNSCC) patient outcomes. In this sense, the sensitization of resistant cells and cancer stem cells (CSCs) represents a major challenge in cancer therapy. We conducted a proteomic study involving cisplatin-resistance and CSCs with the aim to unravel the molecular and cellular mechanisms by which tumor cells acquire resistance to chemotherapy. Syntenin-1 (SDCBP) was identified as an important protein involved in the chemoresistance and stemness of HNSCC tumors.
On the other hand, we have characterize the CIRBP protein as a novel biomarker in breast cancer (luminal tumors).

Group Leader
Matilde Lleonart Pajarin

Principal Investigator (PI)
Juan Lorente Guerrero, Sergi Benavente Norza, Josep Castellvi Vives, Jordi Temprana Salvador

Yoelsis García Mayea

PhD Students
Cristina Mir Pérez, Almudena Sánchez García, Marina Bataller Fernandez

Nursing and Technical Staff
Maria Isabel Rodriguez Hernández








Cristina Mir, Yoelsis Garcia-Mayea, Laia Garcia, Pol Herrero, Nuria Canela, Rocío Tabernero, Juan Lorente, Josep Castellvi, Eva Allonca, Juana García-Pedrero, Juan Pablo Rodrigo, Ángel Carracedo, and Matilde Esther LLeonart
SDCBP Modulates Stemness and Chemoresistance in Head and Neck Squamous Cell Carcinoma through Src Activation
Cancers (Basel). 2021 Oct; 13(19): 4952.
DOI: 10.3390/cancers13194952
IF: 6.639

Takumi Mikawa, Eri Shibata, Midori Shimada, Ken Ito, Tomiko Ito, Hiroaki Kanda, Keiyo Takubo, Atsuyoshi Shimada, Matilde E. Lleonart, Nobuya Inagaki, Masayuki Yokode, Hiroshi Kondoh
Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis
PLoS One. 2021; 16(4): e0250856.
DOI: 10.1371/journal.pone.0250856
IF: 3.24

Alberto Indacochea, Santiago Guerrero, Macarena Ureña, Ferrán Araujo, Olga Coll, Matilde E. LLeonart, Fátima Gebauer
Cold-inducible RNA binding protein promotes breast cancer cell malignancy by regulating Cystatin C levels
RNA. 2021 Feb; 27(2): 190–201.
DOI: 10.1261/rna.076422.120
IF: 4.39

Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard,...LLeonart ME...Chun-Kit Tong
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Autophagy. 2021; 17(1): 1–382.
DOI: 10.1080/15548627.2020.1797280
IF: 16.016

Hiroshi Kondoh, Josep Castellvi, Matilde Esther LLeonart
Editorial: How Do Metabolism, Angiogenesis, and Hypoxia Modulate Resistance?
Front Oncol. 2021; 11: 671222.
DOI: 10.3389/fonc.2021.671222
IF: 4.416

Nuevas aproximaciones terapéuticas en cáncer de cabeza y cuello.
Principal Investigator: Matilde E. LLeonart
Agency: Ministerio de Sanidad
Funding: 180,000 €
Period: 2021-2024

Novel Therapeutic approaches against COVID-19
Principal Investigator: Matilde E. LLeonart
Agency: Fundació La Marató TV3
Funding: 250,000 €
Period: 2022-2025

Tumors of low prevalence
Principal Investigator: Santiago Ramón y Cajal
Agency: Ministerio de Sanidad
Funding: -
Period: 2017-2021