In 2021 we have discovered new proteins associated with vascular beta-amyloid deposition, which may have impact in the improvement of Cerebral Amlyoid Angiopathy diagnosis and development of future therapeutic approaches, and identified other blood biomarkers related to subclinical progression and cognitive impairment in cerebral small vessel disease. We have discovered a panel of blood biomarkers to differentiate between ischemic stroke and intracerebral hemorrhage in patients with suspected stroke (RBP-4, NT-proBNPand GFAP) that might allow prehospital treatment. Finally, we have proved the endovascular administration after arterial reperfusion as a more targeted route to deliver nanomaterials in the brain tissue after cerebral ischemia in mice, and identified novel therapeutic targets to enhance neurorepair. In parallel, thorough several national and international collaborations we have participated in high-impact publications in the neuroscience and cell biology fields.
Group Leader
Anna Rosell Novel
Principal Investigator (PI)
Pilar Delgado, Mar Hernández-Guillamon, Olga Maisterra, Joan Montaner, José Alvarez-Sabín, Francesc Pujades
PhD Students
Mercedes Arrué Gonzalo, Anna Bonaterra Pastra, Júlia Faura Llorens, Paula García Rodríguez, Nicolás García Rodríguez, Alba Grayston Morales, Ting Lei, Paula Marazuela Fuentes, Elena Palà Vila, Laura Ramiro Pascual, Alejandro Ballvé Martin
Lab Technicians
Anna Penalba Morenilla, Miguel García Gabilondo, Feifei Ma
Nursing and Technical Staff
Jesús Pizarro Gonzálvez, Elvira Chocano Navarro, Natàlia Corbeto López, Marcel Lamana Vallverdú
36
PUBLICATIONS
314
IMPACT FACTOR
8.72
AVERAGE IMPACT FACTOR
SELECTED ARTICLES
Paula Marazuela, Montse Solé, Anna Bonaterra-Pastra, Jesús Pizarro, Jessica Camacho, Elena Martínez-Sáez, H Bea Kuiperij, Marcel M Verbeek, Anna M de Kort, Floris H B M Schreuder, Catharina J M Klijn, Laura Castillo-Ribelles, Olalla Pancorbo, David Rodríguez-Luna, Francesc Pujadas, Pilar Delgado, Mar Hernández-Guillamon.
MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
Acta Neuropathologica Communications. 2021 Sep 16;9(1):154.
DOI: doi: 10.1186/s40478-021-01257-9
IF: 7.8
Júlia Faura, Alejandro Bustamante, Francesc Miró-Mur, Joan Montaner
Stroke-induced immunosuppression: implications for the prevention and prediction of post-stroke infections
Journal of Neuroinflammation. 2021 Jun 6;18(1):127.
DOI: doi: 10.1186/s12974-021-02177-0
IF: 8.32
Markus Arnold, Juliane Schweizer, Christos T Nakas, Valerie Schütz, Laura P Westphal, Corinne Inauen, Thomas Pokorny, Andreas Luft, Alexander Leichtle, Marcel Arnold, Antonela Bicvic, Urs Fischer, Gian Marco De Marchis, Leo H Bonati, Mandy D Müller, Timo Kahles, Krassen Nedeltchev, Carlo W Cereda, Georg Kägi, Alejandro Bustamante, Joan Montaner, George Ntaios, Christian Foerch, Katharina Spanaus, Arnold von Eckardstein, Mira Katan
Lipoprotein(a) is associated with large artery atherosclerosis stroke aetiology and stroke recurrence among patients below the age of 60 years: results from the BIOSIGNAL study.
Euroepan Heart Journal. 2021 Jun 7;42(22):2186-2196.
DOI: doi: 10.1093/eurheartj/ehab081
IF: 29.98
Rodrigo Azevedo Loiola, Miguel García-Gabilondo, Alba Grayston, Paulina Bugno, Agnieszka Kowalska, Sophie Duban-Deweer, Eleonora Rizzi, Johan Hachani, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Piotr Mazurek, Anna Rosell, Fabien Gosselet
Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage
Stem Cell Research & Therapy. 2021. Oct 26;12(1):552.
DOI: doi: 10.1186/s13287-021-02608-y
IF: 6.83
Alejandro Bustamante, Anna Penalba, Cyrille Orset, Leire Azurmendi, Víctor Llombart, Alba Simats, Emili Pecharroman, Oriol Ventura, Marc Ribó, Denis Vivien, Jean Charles Sanchez, Joan Montaner
Blood Biomarkers to Differentiate Ischemic and Hemorrhagic Strokes Might Allow Prehospital Thrombolysis.
Neurology. 2021 Apr 13;96(15):e1928-e1939.
DOI: doi: 10.1212/WNL.0000000000011742
IF: 9.91
PRESTIGE-AF “PREvention of STroke in Intracerebral hemorrhaGE survivors with Atrial Fibrillation”.
Principal Investigator: Joan Montaner
Agency: EU-European Comission
Funding: 383,350€
Period: 2017-2023
Redes Temáticas (RETICS). ENFERMEDADES VASCULARES CEREBRALES. INVICTUS PLUS
Principal Investigator: Anna Rosell
Agency: Instituto de Salud Carlos III
Funding: 240,669€
Period: 2017 – 2021
Implicación de proteínas asociadas a beta-amiloide vascular en la Angiopatía Amiloide Cerebral
Principal Investigator: Mar Hernández-Guillamon
Agency: Instituto de Salud Carlos III
Funding: 165,400€
Period: 2021-2023
Identificación de biomarcadores y dianes terapéuticas para la neuroreparación durante la neurorehabilitación tres el ictus.
Principal Investigator: Anna Rosell
Agency: Instituto de Salud Carlos III
Funding: 171,820€
Period: 2020-2022
Demencia mixta por Alzheimer y enfermedad cerebrovascular: un estudio clínico y experimental.
Principal Investigator: Pilar Delgado
Agency: Instituto de Salud Carlos III
Funding: 134,000€
Period: 2020-2022
MARKERS AND THEIR USE IN BRAIN INJURY
Priority Number: EP20382889.2 ES
Priority Date: 08/10/2020
Applicants: 50% VHIR & 50% Univerity of Geneva
METHOD FOR SELECTING A PATIENT FOR A REPERFUSION THERAPY
Priority Number: PCT/EP2020/063726
Priority Date: 15/05/2020
Applicants: 100%VHIR
BIOMARKERS FOR STROKE PROGNOSIS
Priority Number: PCT/EP2020/070152
Priority Date: 16/07/2020
Applicants: 100% VHIR
DIAGNOSIS MARKERS FOR ATRIAL FIBRILLATION
Priority Number: PCT/EP2020/061467
Priority Date: 24/04/2020
Applicants: 100% VHIR
METHODS AND COMPOSITIONS FOR TREATING ISCHAEMIA IN A SUBJECT
Priority Number: PCT/EP2020/070154
Priority Date: 16/07/2020
Applicants: 90% VHIR & 10% ANAXOMICS
