Our research group focuses on two main areas of interest which are related to Solid Organ Transplantation and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well a sthe immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering of kidney diseases aswell as their quality of life reducing associated morbidity and mortality.
Group Leader
Oriol Bestard Matamoros, Maria José Soler Romeo
Principal Investigator (PI)
Francesc Moreso, Concepció Jacobs
Researchers
Elena Crespo, Joana Sellarés, Irina Torres, Manel Perelló, Maria Meneghini, Irene Agraz, Sheila Bermejo, Antonieta Azancot, Natàlia Ramos, Ander Vergara
PhD Students
Mónica Bolufer, Ignacio Cidraque, Marina López, Nestor Toapanta, Alba Torija, Laura Donadeu, Thomas Jouve, Irene Martinez.
Lab Technicians
Núria Bolaños, Mariona Juvé, Maria Tormo, Pamela Domínguez, Carme Llorens, Maria Tormo
Nursing and Technical Staff
Oreto Prat Canet, Emma Pardo de los Santos, Fiona Robert, Carlota Medina
57
PUBLICATIONS
310
IMPACT FACTOR
5.44
AVERAGE IMPACT FACTOR
SELECTED ARTICLES
Soler MJ, Noordzij M, Abramowicz D, de Arriba G, Basile C, van Buren M, Covic A, Crespo M, Duivenvoorden R, Massy ZA, Ortiz A, Sanchez JE, Petridou E, Stevens K, White C, Vart P, Gansevoort RT; ERACODA Collaborators
Renin-angiotensin system blockers and the risk of COVID-19 related mortality in patients with kidney failure
Clinical Journal of the American Society of Nephrology 2021; 16 (7): 1061-1072
DOI: doi: 10.2215/CJN.18961220
IF: 8.240
Bestard O, Meneghini M, Crespo E, Bemelman F, Koch M, Volk HD, Viklicky O, Giral M, Banas B, Ruiz JC, Melilli E, Hu L, van Duivenvoorden R, Nashan B, Thaiss F, Otto NM, Bold G, Stein M, Sefrin A, Lachmann N, Hruba P, Stranavova L, Brouard S, Braudeau C, Blancho G, Banas M, Irure J, Christakoudi S, Sanchez-Fueyo A, Wood KJ, Reinke P, Grinyó JM.
Preformed T-cell alloimmunity and HLA eplet mismatch to guide immunosuppression minimization with Tacrolimus monotherapy in Kidney Transplantation. Results of the CELLIMIN trial
American Journal of Transplantation 2021; 21 (8): 2833-2845
DOI: doi: 10.1111/ajt.16563
IF: 8.086
Favà A, Donadeu L, Sabé N, Pernin V, González-Costello J, Lladó L, Meneghini M, Charmetant X, García-Romero E, Cachero A, Torija A, Rodriguez-Urquia R, Crespo E, Teubel I, Melilli E, Montero N, Manonelles A, Preyer R, Strecker K, Ovize A, Lozano JJ, Sidorova J, Cruzado JM, Le Quintrec M, Thaunat O, Bestard O
SARS-CoV-2-specific serological and funcional T-cell immune responses during acute and early COVID-19 convalescence in solid organ transplantation patients
American Journal of Trasplantation 2021; 21 (8): 2749-2761
DOI: doi: 10.1111/ajt.16570
IF: 8.086
Meneghini M, Crespo E, Niemann M, Torija A, Lloberas N, PerninV, Fontova P, Melilli E, Favà A, Montero N, Manonelles A, Cruzado JM, Palou E, Martorell J, Grinyó JM, Bestard O.
Donor/recipient HLA molecular mismatch scores predict primary humoral and cellular alloimmunity in kidney transplantation
Frontiers in Immunology 2021; 11: 623276
DOI: doi: 10.3389/fimmu.2020.623276
IF: 7.561
Bobart SA, Han H, Tehranian S, De Vriese AS, Roman JCL, Sethi S, Zand L, Andrades Gomez C, Giesen CD, Soler MJ*, Bomback AS, Fervenza FC*
Noninvasive Diagnosis of PLA2R-Associated Membranous Nephropathy: A Validation Study
Clinical Journal of the Americal Society of Nephrology 2021; 16 (12): 1833–1839
DOI: doi: 10.2215/CJN.05480421.
IF: 8.240
DECIPHERING THE MECHANISMS OF PLA2R-SPECIFIC B-CELL AUTOIMMUNITY IN PRIMARY MEMBRANOUS NEPHROPATHY (PMN) (BCELL-MEM) (coordinated by Hospital Universitari de Bellvitge -HUB and Hospital Universitari Vall d’Hebron)
Principal Investigator: Maria José Soler Romeo
Agency: Fundació La Marató TV3
Funding: 100,767.50 €
Period: 2021-2023
FUNCTIONAL IMMUNE-MONITORING OF VIRUS-SPECIFIC T AND B-CELL RESPONSES IN SOLID ORGAN TRANSPLANT RECIPIENTS RECEIVING SARS-CoV-2 VACCINATION (MoniToR)
Principal Investigator: Oriol Bestard Matamoros
Agency: Fundació La Marató TV3
Funding: 299,500.00 €
Period: 2021-2023
THE EUROPEAN TRANSPLANTATION AND INNOVATION CONSORTIUM FOR RISK STRATIFICATION IN KIDNEY TRANSPLANT PATIENTS
Principal Investigator: Oriol Bestard Matamoros
Agency: European Union
Funding: 902,892.00 €
Period: 2018-2022
RELACIÓN ENTRE LOS NIVELES DE TACROLIMUS Y/O LA DOSIS DE MICOFENOLATO Y LA MODULACIÓN DE LOS GENES DE RECHAZO EN BIOPSIAS DE SEGUIMIENTO DEL ALOINJERTO RENAL
Principal Investigator: Daniel Serón Micas
Agency: Fondo Investigaciones Sanitarias, Instituto Carlos III
Funding: 81,070.00 €
Period: 2019 - 2021
MODELO PREDICTIVO DEL RIESGO DE INFECCIÓN Y RECHAZO BASADO EN LA COMBINACIÓN DE PARÁMETROS CLÍNICAS Y BIOMARCADORES
Principal Investigator: Francesc Moreso Mateos
Agency: Fondo Investigaciones Sanitarias, Instituto Carlos III
Funding: 87,120.00 €
Period: 2019 - 2021
LABORATORY DEVICE FOR COLLECTING OF ANIMAL SAMPLES
Priority Number: 202131356
Priority Date: 29/06/2021
Applicants: 100% VHIR
