The Bioengineering, Cellular Therapy and Congenital Malformation Surgery research group is made up of clinical researchers (pediatric surgeons, neonatologists and obstetricians) and basic researchers (biochemists, biotechnologists and biologists), which makes up a large multidisciplinary team with extensive experience in biomedical and clinical research. The objectives of the different lines of research carried out are the study of human congenital malformations, the development of new therapies based on advanced surgical techniques, as well as cell and pharmacological therapy to promote tissue regeneration for therapeutic purposes. During 2021, our team has published 14 scientific articles and is working on competitive financing projects of excellence at the national (CDTI) and international (H2020) levels for the study of innovative therapies in osteoarticular pathology and regenerative medicine.

Group Leader
Manuel López Paredes

Principal Investigator (PI)
Carles Giné Prades, Mario Marotta Baleriola, Francisco Soldado Carrera

Marino Asensio Llorente, Romy Gander, Gloria Royo Gomes, Jorge Knörr Giménez, Ana Lain Fernandez, Sergio Lopez Fernandez, José Andrés Molino Gahete, José Luis Peiró Ibáñez

PhD Students
María Díaz Hervás, Rodrigo Maluje Juri, Marta Marin Soro, Laura Vidal Fornells, Ingrid Vila Fernández

Lab Technicians
Cristina Fernández García, Adrián García Rodríguez, Anabel Sacristán Ruiz








Contreras-Muñoz P, Torrella JR, Venegas V, Serres X, Vidal L, Vila I, Lahtinen I, Viscor G, Martínez-Ibáñez V, Peiró JL, Järvinen TAH, Rodas G, Marotta M.
Muscle Precursor Cells Enhance Functional Muscle Recovery and Show Synergistic Effects With Postinjury Treadmill Exercise in a Muscle Injury Model in Rats.
Am J Sports Med. 2021 Mar;49(4):1073-1085.
DOI: doi: 10.1177/0363546521989235. PMID: 33719605.
IF: 6.20

Domenech-Fernandez P, Yamane J, Domenech J, Barrios C, Soldado-Carrera F, Knorr J, Canavese F.
Early Changes in Blood Urea Nitrogen (BUN) Can Predict Mortality in Acute Pancreatitis: Comparative Study between BISAP Score, APACHE-II, and Other Laboratory Markers-A Prospective Observational Study.
Eur Spine J. 2021 Feb;30(2):410-415.
DOI: doi: 10.1007/s00586-020-06367-x. Epub 2020 Apr 4. Erratum in: Eur Spine J. 2020 May 13;: PMID: 32248506.
IF: 3.13

Laín A, Giralt G, Giné C, García Martínez L, Villaverde I, López M.
Transesophageal echocardiography during pectus excavatum correction in children: What happens to the heart?
J Pediatr Surg. 2021 May;56(5):988-994.
DOI: doi: 10.1016/j.jpedsurg.2020.06.009. Epub 2020 Jun 12. PMID: 32660778.
IF: 2.55

García I, Suárez E, Maiz N, Pascual M, Perera R, Arévalo S, Giné C, Molino JA, López M, Carreras E, Manrique S.
Fetal heart rate monitoring during fetoscopic repair of open spinal neural tube defects: a single-centre observational cohort study.
Int J Obstet Anesth. 2021 Nov;48:103195.
DOI: doi: 10.1016/j.ijoa.2021.103195. Epub 2021 Jun 8. PMID: 34175576.
IF: 2.60

Fernandez-Garcia C, Montaner-Ramon A, Hernandez-Perez S, Camba-Longueira F, Ribes-Bautista C, Frick MA, Castillo-Salinas F.
Severe COVID-19 during pregnancy and the subsequent premature delivery.
Pediatr Neonatol. 2021 Jan;62(1):113-114.
DOI: doi: 10.1016/j.pedneo.2020.09.005. Epub 2020 Sep 19. PMID: 33039313; PMCID: PMC7501516.
IF: 2.08

BioprintIA: Investigación industrial de nuevas tecnologías para el tratamiento personalizado de patologías osteoarticulares de rodilla a través de Inteligencia Artificial e implantes celularizados generados mediante bioimpresión 3D
Principal Investigator: Francisco Soldado Carrera
Agency: Centro para el Desarrollo Técnico Industrial (CDTI)-Programa MISIONES (Salud)- MIG-20201046
Funding: 153,300 €
Period: 2020-2023

TRIANKLE: 3D Bioprinted personalised scaffolds for tissue regeneration of ankle joint.
Principal Investigator: Mario Marotta Baleriola
Agency: European Commission - H2020-NMBP-TR-IND-2020 (Grant agreement: 952981)
Funding: 713,750 €
Period: 2020-2024

SBR: Smart Bone Regeneration (SBR).
Principal Investigator: Mario Marotta Baleriola
Agency: European Commission - H2020-SC1-BHC-07-2019 (Grant agreement: 874896)
Funding: 854,335 €
Period: 2019-2023

PI18/01825: Terapia celular para la regeneración neural y el tratamiento del mielomeningocele en modelo experimental de feto de oveja
Principal Investigator: Carles Giné Prades
Agency: Instituto de salud Carlos III, PI18/01825
Funding: 83,490 €
Period: 2017-2023

nTRACK: Multimodal nanoparticles for structural and functional tracking of stem cell therapy on muscle regeneration.
Principal Investigator: Mario Marotta Baleriola
Agency: European Commission - H2020-NMBP-2016-2017 (Grant agreement: 761031)
Funding: 1,019,687.50 €
Period: 2017-2022